Life in Death

securitization of mortality risks in life annuities

insurers have in the past few decades faced longevity risks - the risk that annuitants survive more than expected - and therefore need a new approach to manage this new risk. in this dissertation we survey methods that hedge longevity risks. these methods use securitization to manage risk, so using modern financial and insurance pricing models, especially wang transform and actuarial concepts, ...

Life & Death

life insurance policy (college freshman), about the same as the Gettysburg Address, and much less readable than Hemingway (fifth grade level). I used more words per sentence than Hemingway (18.5 versus 13.5) but less than Lincoln (26.8). I used longer words than any of the references (4.8 letters per word, versus 4.0 for Hemingway) but used fewer prepositions (10.7 percent) than any of the othe...

p53 in life and death.

Introduction One of the supreme challenges faced in cancer therapy is the small therapeutic window afforded by chemotherapeutic agents and radiation therapy. Many of these agents act by damaging DNA. This DNA damage is believed to be directly lethal to rapidly growing cancer cells but also produces toxicity through effects on normal cells. A major therapeutic research goal in molecular oncology...

Chaperonins: In life and death

The Hsp60 family proteins, also known as “chaperonins”, are a highly conserved subgroup of molecular chaperones found in all organisms with many species having multiple forms. This family includes the bacterial GroEL, mitochondrial Hsp60, plastid Rubisco subunit binding protein, archaeagroup II chaperonins and eukaryotic cytosolic TCP-1 proteins. These proteins are usually expressed constitutiv...

Relitigating life and death.